Inflammation, Endotoxins and Lipedema

In today’s episode, we’ll talk about a paper that discusses a potential pathway for chronic low-grade inflammation to occur in lipedema, which contributes to resistance to fat loss and promotes further adipose tissue expansion.

The paper is titled, “Is the endotoxin–complement cascade the major driver in lipedema?” by Dr. Kruglikov from Germany and Dr. Scherer from the USA.

It was published in the peer-reviewed journal Trends in Endocrinology & Metabolism in September 2024.

This paper is important for individuals with lipedema because it offers another possible option for intervention and management of troubling symptoms of lipedema.

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About the Podcast

Living Well with Lipedema

Lipedema, the disease they call fat, is a chronic fat disorder that affects 17 million women in the USA and as many as 350 million women worldwide. It is often mistaken for simple obesity. Generally under-recognized and misdiagnosed, symptoms include pain, swelling and weight gain disproportionately distributed in the thighs, buttocks, legs, and hips with a smaller upper body. Lipedema fat is resistant to diet and exercise and without intervention progresses and worsens over time. This flash briefing offers tips, news, and updates with the founder and director of Lipedema Simplified, Catherine A. Seo, Ph.D., Lipedema Project Board President and Director of Research, Leslyn Keith, OTD, CLT-LANA, and guest experts. Please note DISCLAIMER The information in Living Well with Lipedema is provided for informational and educational purposes only.

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About your host

Catherine Seo

About CATHERINE SEO, PhD
Catherine is Founder & Director of Lipedema Simplified & The Lipedema Project and a professor of psychology. She produced and directed the documentary, The Disease They Call FAT, and was a co-author of the book, Lipedema-The Disease They Call FAT: An Overview for Clinicians. She holds a doctorate in Psychology with a concentration in Media. She has developed online courses on lipedema for patients and healthcare professionals as well as multi-media learning tools since 2013 and is the Director of the MasterClass Program, courses and webinars.

About LESLYN KEITH, OTD, CLT-LANA
Leslyn is President & Director of Research for The Lipedema Project, an instructor in lymphedema therapy for Klose Traning and Consulting, and has a private practice in lymphedema/lipedema therapy. She has completed research about lifestyle change, including a ketogenic way of eating, for participants who were diagnosed with lymphedema and obesity. Leslyn has a doctorate in Occupational Therapy and has been treating lymphatic disorders since 2000.